McCune-Albright Syndrome
Some individuals with fibrous dysplasia also may develop hormonal problems such as early puberty, hyperthyroidism, excessive secretion of several pituitary hormones, and high blood calcium from parathyroid hormone. Individuals with hormonal disturbances also may exhibit areas of darkly pigmented skin called "café-au-lait," or "coffee-milk" spots. The combination of fibrous dysplasia, hormonal disturbances, and skin pigmentation is called McCune-Albright syndrome, named for Dr. Donovan McCune and Dr. Fuller Albright, who independently described the syndrome in 1937. Patients who have fibrous dysplasia in only one bone usually do not develop McCune-Albright syndrome. The genetic abnormality that has been found in bone is also found in other tissues that have abnormal function.
Content Courtesy : www.osteo.org
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